Common Painkillers Could Be Fueling Deadly Superbugs, Scientists Warn

By The Blogging Hounds Two of America’s most widely used over-the-counter painkillers — ibuprofen (Advil) and acetaminophen (Tylenol) — may be unintentionally helping bacteria evolve into deadly, antibiotic-resistant superbugs, according to a startling new study. Researchers warn that these everyday medications could be exacerbating one of the world’s most urgent public health crises. Painkillers Driving…

By The Blogging Hounds

Two of America’s most widely used over-the-counter painkillers — ibuprofen (Advil) and acetaminophen (Tylenol) — may be unintentionally helping bacteria evolve into deadly, antibiotic-resistant superbugs, according to a startling new study. Researchers warn that these everyday medications could be exacerbating one of the world’s most urgent public health crises.

Painkillers Driving Antibiotic Resistance
Scientists at the University of South Australia tested E. coli bacteria in the lab alongside ciprofloxacin, a common antibiotic used for urinary tract infections. The results were alarming: both ibuprofen and acetaminophen individually accelerated genetic mutations in the bacteria, and when combined, they amplified the effect. These mutations made the bacteria highly resistant to ciprofloxacin and other antibiotics.

“Antibiotic resistance isn’t just about antibiotics anymore,” said Associate Professor Rietie Venter, lead author of the study. The research underscores how medications beyond antibiotics — including painkillers, antidepressants, and other commonly used drugs — can contribute to antimicrobial resistance (AMR).

High-Risk Environments and Elder Care
The study highlights particular concerns in settings where multiple medications are routinely administered, such as elder care facilities. Residents often receive combinations of painkillers, sleeping aids, decongestants, and other medications, creating an environment ripe for resistant superbugs to emerge.

The Global Threat of Superbugs
The World Health Organization classifies AMR as one of the top global public health threats. In 2019, drug-resistant bacteria caused 1.27 million deaths and were associated with nearly five million more. If trends continue, AMR-related deaths could soar to nearly 40 million over the next 25 years.

Practical Recommendations
Experts stress this doesn’t mean people should stop using common painkillers, but caution is advised, especially when combined with antibiotics. Healthcare providers are encouraged to review medication schedules in high-risk populations and consider safer alternatives when possible. Completing full antibiotic courses and avoiding unnecessary prescriptions remain critical steps in curbing the AMR crisis.

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