Veterinary Replicon Vaccines

Massive Genetic Effort in Veterinary Medicine Described as “Elegant”

The news has been full for months with stories about striking Dutch farmers, Chinese acquisition of foreign farms, projected food shortages, and now vaccination of plants and animals in the food supply. Compared with human medicine, veterinary medicine is far ahead in genetic vaccine technologies. One of the reasons is that the life cycle of a livestock is sufficiently short that clinical studies simply aim to demonstrate efficacy with reasonable safety as a secondary goal.

Hikke and Pijlman describe “replicon” vaccines in development and approved products. “To increase the potency by stimulating multiple immune pathways simultaneously, nucleic acid vaccines based on self-replicating viral RNAs (replicon vaccines) have been developed. An important feature that sets replicon vaccines apart from LAV or viral-vectored vaccines is their inability to spread from cell to cell. Replicons do not code for viral structural proteins required for encapsidation but instead code for a heterologous gene of interest. Thus, replicons are not infectious and are limited to a single round of replication. In its most simple form, a replicon is a cloned viral complementary DNA (cDNA) with the structural genes removed.”

Hikke MC, Pijlman GP. Veterinary Replicon Vaccines. Annu Rev Anim Biosci. 2017 Feb 8;5:89-109. doi: 10.1146/annurev-animal-031716-032328. Epub 2016 Nov 14. PMID: 27860492.

One could imagine the danger if such a “replicon” was devised for humans, but coded for a foreign and damaging protein such as the WIV SARS-CoV-2 Spike or Influenza hemagglutinin (HA). The inability to not only shut off antigen production but to control continued amplification beyond one round of RNA could overwhelm the body with damaging antigen production. Expression of foreign proteins/antigens on the cell surface over time is bound to generate autoimmunity and a variety of problems.

In summary, safety for veterinary use is not the same as for human use. We will need to take a careful look at advances in human medicine that attempt to parallel those taken with farm animals, livestock, and other elements of the food supply.


You’ll find Dr Ardis’ suggested supplements right below.

CLICK HERE to read articles on Antiviral activity of animal venom peptides and related compounds

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